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This method is common in animal models to study systemic or localized but deeper tissue effects

This cohort study demonstrates a decreased risk of myocardial infarction among patients with psoriasis who were treated with TNF inhibitors, with key implications about the potential systemic effect of psoriasis and the broader role of treatments on patient health

However, because of these differences of opinion as to whether this effect occurs with finasteride, FDA in 2011 announced to revise the 5ARI class of drugs with their new safety information

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